Genetic and neuroimaging of neuropsychiatric conditions

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    Publications

    Recent articles

    Neuropsychiatric mutations delineate functional brain connectivity dimensions contributing to autism and schizophrenia

    16p11.2 and 22q11.2 Copy Number Variants may represent mechanistic building blocks shared across idiopathic conditions.

    Differential effects of deletions and duplications on autism risk across the genome

    Autism risk conferred by duplications is less influenced by IQ compared to deletions. CNVs increase autism risk similarly in individuals with high and low IQ.

    Developmental trajectories of neuroanatomical alterations associated with the 16p11.2 Copy Number Variations

    All large effect-size voxel-based differences are present at 4.5 years and seem to remain stable until the age of 23.

    Projects

    We are working on....

    CNVs prediction tools

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    Brain connectivity of neuropsychiatric mutations

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    Deletion effect on cognition

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    SNV xx

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    Brain morphometry

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    Polygenic risk score

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    Team

    Sebastien Jacquemont

    Lab director - Geneticist

    Guillaume Huguet

    Research associate

    Clara Moreau

    Postdoc - Neuroimaging

    Laura Peyras

    Assistant

    CNV prediction

    This tool was created to help clinicians estimate the potential impact of deletions in the genome (hg19 genomic map) on cognition based on the results of Huguet et al. (JAMA psychiatry 2018).

    Try out our tools!